Ru(ii)-Catalyzed, Cu(ii)-mediated carbene migratory insertion in the synthesis of trisubstituted pyrroles from isoxazoles

Abstract

A convenient, “one-pot” synthesis of trisubstituted pyrroles via a Ru(II)-catalyzed, Cu(II)-mediated reaction of substituted isoxazoles with sulfonylhydrazones has been developed. A series of highly functionalized pyrroles are obtained via a synergistic formation of new C−C and C−N bonds. Mechanistic investigations were carried out to propose the plausible pathway. This protocol provides a facile and expeditious approach for the synthesis of various heterocyclic compounds bearing the pyrrole skeleton.