Visible light-induced alkylpyridylation of styrenes via a reductive radical three-component coupling

Abstract

A visible light-induced and metal-free strategy for the intermolecular three-compoment alkylpyridylation of styrenes is reported. Hantzsch ester was found to be key to initiate the overall reductive radical coupling reaction. This radical process realized difunctionalization of styrenes, selectively yielding alkylated pyridines in good to excellent yields with a wide tolerance of functional groups, mild reaction conditions and simple operation. This new reaction complements existing visible light-induced variants of styrenes with NHP esters and expands the capabilities of radical-based cross-coupling reactions of pyridines.