Issue 30, 2021

Asymmetric bis(oxazoline)–Ni(ii) catalyzed α-hydroxylation of cyclic β-keto esters under visible light

Abstract

Using visible light as a driving force and molecular oxygen as a green oxidant, we developed bis(oxazoline)–Ni(acac)2 catalyzed asymmetric α-hydroxylation of β-keto esters under low photosensitizer loading, and the protocol enabled an efficient transformation to provide the desired chiral α-hydroxy-β-keto esters in high yields (up to 99%) and enantioselectivities (up to 99% ee) at room temperature.

Graphical abstract: Asymmetric bis(oxazoline)–Ni(ii) catalyzed α-hydroxylation of cyclic β-keto esters under visible light

Supplementary files

Article information

Article type
Communication
Submitted
20 Mar 2021
Accepted
12 May 2021
First published
12 May 2021

Org. Biomol. Chem., 2021,19, 6588-6592

Asymmetric bis(oxazoline)–Ni(II) catalyzed α-hydroxylation of cyclic β-keto esters under visible light

H. Yin, C. Wang, Y. Zhao, Z. He, M. Chu, Y. Wang and D. Xu, Org. Biomol. Chem., 2021, 19, 6588 DOI: 10.1039/D1OB00546D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements