Issue 34, 2021

Sequence-controlled and sequence-defined polypeptoids via the Ugi reaction: synthesis and sequence-driven properties

Abstract

Polypeptoids are peptidomimetic polymers, and their origin can be traced back to the early 1990s. The facile synthesis of sequence-controlled and sequence-defined polypeptoids still faces many challenges. Very recently, the Ugi reaction has been introduced into polypeptoid chemistry. In this mini review, the recent progress in the application of the Ugi reaction for the synthesis of sequence-controlled polypeptoids is summarized. The influence of the sequence structure on polypeptoid properties is presented. Moreover, the future development of the Ugi reaction for the synthesis of sequence-controlled and sequence-defined polypeptoids is discussed.

Graphical abstract: Sequence-controlled and sequence-defined polypeptoids via the Ugi reaction: synthesis and sequence-driven properties

Article information

Article type
Minireview
Submitted
15 May 2021
Accepted
18 Jul 2021
First published
19 Jul 2021

Polym. Chem., 2021,12, 4895-4902

Sequence-controlled and sequence-defined polypeptoids via the Ugi reaction: synthesis and sequence-driven properties

Y. Zhu and Y. Tao, Polym. Chem., 2021, 12, 4895 DOI: 10.1039/D1PY00658D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements