A metal-free direct synthesis of pyrimidines from amidine hydrochlorides, ketones and DMSO through substrate-induced DMSO activation and subsequent reactions has been developed. In this protocol, amidine hydrochlorides were not only used as reactants but also activated DMSO to form a sulfenium ion intermediate which then participated in the reactions.
A. Wang, X. Liu, Y. Kong, J. Wang and T. Jiang, Org. Chem. Front., 2021, 8, 947 DOI: 10.1039/D0QO01416H
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