Issue 9, 2021

Copper-catalyzed one-pot synthesis of 2-(2,2,2-trifluoroethyl)-substituted benzofused heterocycles

Abstract

A novel synthesis approach for the construction of 2-trifluoroethyl-substituted benzofurans under copper-catalyzed conditions has been developed. The reaction of salicylaldehyde p-tosylhydrazones with 2-bromo-3,3,3-trifluoropropene proceeded through a sequential process to afford products in moderate to excellent yields (up to 93%). This method is also applicable to the formation of 2-trifluoroethylated indoles.

Graphical abstract: Copper-catalyzed one-pot synthesis of 2-(2,2,2-trifluoroethyl)-substituted benzofused heterocycles

Supplementary files

Article information

Article type
Research Article
Submitted
28 Jan 2021
Accepted
26 Feb 2021
First published
01 Mar 2021

Org. Chem. Front., 2021,8, 1997-2001

Copper-catalyzed one-pot synthesis of 2-(2,2,2-trifluoroethyl)-substituted benzofused heterocycles

W. Wu, B. Luo, Y. You and Z. Weng, Org. Chem. Front., 2021, 8, 1997 DOI: 10.1039/D1QO00157D

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