Iron-catalyzed para-selective C–H silylation of benzamide derivatives with chlorosilanes

Abstract

Site-selective C–H silylation has emerged as an efficient tool that can be used to simplify the synthesis of organosilicon compounds; however, catalytic para-selective C–H silylation of electron-deficient arenes has remained a much less explored area. Herein, we report an iron-enabled para-selective C–H silylation of benzamide derivatives with chlorosilanes, which constitutes an efficient and general route for the synthesis of a wide range of para-silicon functionalized benzamides from easily accessible starting materials.