Controllable regio- and stereo-selective coupling reactions of homoallenylboronates

Abstract

Unprecedented palladium-catalysed regio- and stereo-selective coupling reactions of homoallenylboronates with (hetero)aryl iodides, allyl bromides and alkynyl bromides in aqueous solution were successfully developed. The corresponding 1,3-dienes, skipped dienes and conjugate enynes were obtained as products, respectively, in high yields and with specific stereoselectivity. Therefore, the homoallenylboronates were potentially powerful and flexible “platform” molecules to form the complex 1,3-dienyl compounds.