Issue 17, 2021
From the journal:

Organic Chemistry Frontiers

Brønsted acid and Lewis acid co-promoted cascade cyclization reaction and application to the total synthesis of Erysotramidine†

Xiaolin Ju,‡a   Xiaojun Hu,‡a   Hongliang Shi,a   Shiqiang Ma,a   Feifei He,a   Xiaolei Wang, ORCID logo a   Xingang Xie ORCID logo a  and  Xuegong She ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China
E-mail: shexg@lzu.edu.cn

Abstract

A Brønsted acid and Lewis acid co-promoted cascade cyclization reaction was developed for the concise synthesis of disubstituted pyrrolo [2,1-a] isoquinolines. The developed method was also successfully applied to the total synthesis of erythrina alkaloid Erysotramidine.

Graphical abstract: Brønsted acid and Lewis acid co-promoted cascade cyclization reaction and application to the total synthesis of Erysotramidine

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Article information

DOI
https://doi.org/10.1039/D1QO00668A
Article type
Research Article
Submitted
28 Apr 2021
Accepted
22 Jun 2021
First published
23 Jun 2021

Org. Chem. Front., 2021,8, 4839-4844

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Brønsted acid and Lewis acid co-promoted cascade cyclization reaction and application to the total synthesis of Erysotramidine

X. Ju, X. Hu, H. Shi, S. Ma, F. He, X. Wang, X. Xie and X. She, Org. Chem. Front., 2021, 8, 4839 DOI: 10.1039/D1QO00668A

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