Directional growth of octacalcium phosphate using micro-flow reactor mixing and subsequent aging

Abstract

Well-defined belt-shaped particles of octacalcium phosphate were prepared by mixing aqueous solutions of calcium acetate and that of sodium phosphate monobasic with the aid of a micro-flow reactor. Higher crystallinity and narrower particle size distribution were achieved by the micro-flow reactor if compared with the results of the batch reaction using the same solutions. The width of the belt was controlled by the mixing temperature (0.8 and 2.3 μm for the preparation at 50 and 70 °C, respectively). Post mixing aging at 50 °C, resulted in the directional growth of belt-shaped particles to obtain particles with the length of 17 μm (aspect ratio of 53). XRD and TEM analysis indicated that the micro-flow reactor could separate nucleation and growth allowing preferential growth along the a-direction.