Issue 48, 2021
From the journal:

RSC Advances

Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications

Burcin Izbudak,†a   Berivan Cecen,†bcd   Ingrid Anaya,†e   Amir K. Miri,bc   Ayca Bal-Ozturk ORCID logo *af  and  Erdal Karaoz*agh  

* Corresponding authors

a Department of Stem Cell and Tissue Engineering, Institute of Health Sciences, Istinye University, Istanbul, Turkey
E-mail: aycabal@gmail.com, ekaraoz@istinye.edu.tr

b Biofabrication Lab, Department of Mechanical Engineering, Rowan University, Glassboro, NJ, USA

c School of Medical Engineering, Science and Health, Rowan University, Camden, NJ, USA

d Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Istinye University, Zeytinburnu, Istanbul, Turkey

e Department of Bioengineering, Tecnológico de Monterrey, Campus Monterrey, CP, Monterrey, Nuevo León, México

f Department of Analytical Chemistry, Faculty of Pharmacy, Istinye University, Istanbul, Turkey

g Department of Histology and Embryology, Faculty of Medicine, Istinye University Istanbul, Turkey

h Center for Regenerative Medicine and Stem Cell Research and Manufacturing (LivMedCell), Istanbul, Turkey

Abstract

Layered double hydroxides (LDHs), when incorporated into biomaterials, provide a tunable composition, controllable particle size, anion exchange capacity, pH-sensitive solubility, high-drug loading efficiency, efficient gene and drug delivery, controlled release and effective intracellular uptake, natural biodegradability in an acidic medium, and negligible toxicity. In this review, we study potential applications of LDH-based nanocomposite scaffolds for tissue engineering. We address how LDHs provide new solutions for nanostructure stability and enhance in vivo studies' success.

Graphical abstract: Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications

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Article information

DOI
https://doi.org/10.1039/D1RA03978D
Article type
Review Article
Submitted
22 May 2021
Accepted
31 Aug 2021
First published
09 Sep 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 30237-30252

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Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications

B. Izbudak, B. Cecen, I. Anaya, A. K. Miri, A. Bal-Ozturk and E. Karaoz, RSC Adv., 2021, 11, 30237 DOI: 10.1039/D1RA03978D

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