Issue 45, 2021, Issue in Progress
From the journal:

RSC Advances

Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams†

Zixu Gan,a   Ke Zhang,a   Peng Shi,b   Yingsheng Zhao ORCID logo *a  and  Runsheng Zeng ORCID logo *a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China
E-mail: yszhao@suda.edu.cn, zengrunsheng@suda.edu.cn

b Institute of Organic Chemistry, RWTH Aachen University, Landoltweg1, 52074 Aachen, Germany

Abstract

A novel Cu(CH3CN)4PF6-catalyzed carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform to afford 4-(2,2,2-trichloroethyl)-β-lactams is described. The reaction proceeded at 110 °C in air with di-t-butyl peroxide. Preliminary studies indicated that the reaction undergoes a free radical mechanism via a Cu(I)/Cu(II)/Cu(III) catalytic cycle.

Graphical abstract: Copper(i)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1RA05233K
Article type
Paper
Submitted
07 Jul 2021
Accepted
11 Aug 2021
First published
19 Aug 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 28081-28084

Permissions

Request permissions

Copper(I)-catalyzed radical carboamination reaction of 8-aminoquinoline-oriented buteneamides with chloroform: synthesis of-β-lactams

Z. Gan, K. Zhang, P. Shi, Y. Zhao and R. Zeng, RSC Adv., 2021, 11, 28081 DOI: 10.1039/D1RA05233K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements