Engineered N-doped graphene quantum dots/CoFe2O4 spherical composites as a robust and retrievable catalyst: fabrication, characterization, and catalytic performance investigation in microwave-assisted synthesis of quinoline-3-carbonitrile derivatives

Abstract

Nitrogen-doped graphene quantum dots (N-GQDs), which are less than 10 nm in size, are an interesting member of the nanocarbon materials family. N-GQDs nanostructures have been broadly applied in various fields, such as drug-gene delivery systems, photocatalytic reactions, and catalysts, owing to their unique properties. However, N-GQDs have rarely been introduced as a catalyst in organic synthesis. Herein, CoFe₂O₄ nanocomposites with diverse morphologies are fabricated in various conditions (e.g. green routes, various pH adjusters, temperatures). Due to further active sites on the surface of the nanocomposites, morphology engineering can be effective in catalytic activities. Following the synthesis, the catalytic activity of the engineered CoFe₂O₄ nanocomposites was screened, and it presented the order of spherical > rod > prism > cubic. The uniform spherical morphology provides more accessible active sites. Then, the novel nano-sized N-GQDs/CoFe₂O₄ magnetic spherical composite was readily fabricated by a green, low-cost, and easy hydrothermal route. The engineered composite was applied as an efficient magnetic nanocatalyst for the MW-assisted one-pot synthesis of new and known quinoline-3-carbonitrile derivatives (83–96%) in the shortest reaction time (60–90 s). Furthermore, the green route, easy separation of the nanocatalyst, and reusability (7 runs) without noticeable loss of catalytic efficiency are other advantages.