Issue 20, 2021

Inhibiting quinolone biosynthesis of Burkholderia

Abstract

2-Alkylquinolones are important signalling molecules of Burkholderia species. We developed a substrate-based chemical probe against the central quinolone biosynthesis enzyme HmqD and applied it in competitive profiling experiments to discover the first known HmqD inhibitors. The most potent inhibitors quantitatively blocked quinolone production in Burkholderia cultures with single-digit micromolar efficacy.

Graphical abstract: Inhibiting quinolone biosynthesis of Burkholderia

Supplementary files

Article information

Article type
Edge Article
Submitted
09 Nov 2020
Accepted
24 Mar 2021
First published
26 Mar 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2021,12, 6908-6912

Inhibiting quinolone biosynthesis of Burkholderia

M. Prothiwa, V. Filz, S. Oehler and T. Böttcher, Chem. Sci., 2021, 12, 6908 DOI: 10.1039/D0SC06167K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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