Mitochondria and lysosome-targetable fluorescent probes for hydrogen peroxide

Abstract

Hydrogen peroxide (H₂O₂), as a key member of the reactive oxygen species (ROS), has a certain regulatory effect on many physiological processes, such as cell proliferation, differentiation and migration. However, abnormal production of H₂O₂ can cause diseases including cancer, Alzheimer's disease, cardiovascular disease, and so on. Therefore, it is important to detect changes in H₂O₂ at the subcellular level. In recent years, many fluorescent probes for H₂O₂ have been developed and used in living cells. In this review, we introduce some typical fluorescent probes for H₂O₂ with mitochondrial and lysosomal targeting. This review contains targeting strategies, detection mechanisms, optical characteristics and cell imaging of these probes.