Issue 2, 2021
From the journal:

Journal of Materials Chemistry B

Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy†

Yang Gao,‡ab   Zhibin Yin,‡a   Qian Ji,*c   Jiabing Jiang,c   Zhengzheng Tao,c   Xiaolong Zhao,a   Sijia Sun,a   Aiguo Wu ORCID logo *b  and  Leyong Zeng ORCID logo *a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Environmental Science, Institute of Life Science and Green development, Hebei University, Baoding 071002, P. R. China
E-mail: zengly@hbu.cn

b Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, P. R. China
E-mail: aiguo@nimte.ac.cn

c Department of Radiology, Tianjin First Central Hospital, First Central Clinical College of Tianjin Medical University, Tianjin, P. R. China
E-mail: jiqianq@aliyun.com

Abstract

Multifunctional nanoprobes with tumor microenvironment response are playing important roles in highly efficient theranostics of cancers. Herein, a kind of theranostic nanoprobe was synthesized by coating manganese dioxide (MnO2) on the surface of black commercial P25 titanium dioxide (b-P25). The resultant nanoprobe (b-P25@MnO2) possessed glutathione (GSH)-responsive magnetic resonance (MR) imaging and enhanced photothermal therapy (PTT). In tumor microenvironments, the excessive GSH was consumed by reacting with MnO2 to generate Mn2+ for GSH-responsive MR imaging, in which the longitudinal relaxation rate of b-P25@MnO2 was up to 30.44 mM−1 s−1, showing excellent cellular and intratumoral MR imaging. Moreover, the prepared b-P25@MnO2 exhibited stable and strong photothermal conversion capability with a high photothermal conversion efficiency of 30.67%, by which the 4T1 tumors disappeared completely, indicating safe and highly efficient PTT performance. The current work developed GSH-responsive b-P25@MnO2 nanoprobes, demonstrated for MR imaging and enhanced PTT in cancers.

Graphical abstract: Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy

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Article information

DOI
https://doi.org/10.1039/D0TB02514C
Article type
Paper
Submitted
23 Oct 2020
Accepted
26 Nov 2020
First published
26 Nov 2020

J. Mater. Chem. B, 2021,9, 314-321

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Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy

Y. Gao, Z. Yin, Q. Ji, J. Jiang, Z. Tao, X. Zhao, S. Sun, A. Wu and L. Zeng, J. Mater. Chem. B, 2021, 9, 314 DOI: 10.1039/D0TB02514C

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