Fabrication of an injectable hydrogel with inherent photothermal effects from tannic acid for synergistic photothermal-chemotherapy

Abstract

Developing injectable hydrogels with near-infrared (NIR)-responsive photothermal effects has increasingly become a promising strategy for local cancer treatment via combinational photothermal-chemotherapy. Herein, a biocompatible hydrogel with a remarkable shear-thinning and recovery capability for injection application was fabricated from 4-arm-PEG-SH and tannic acid through chemical crosslinking and multiple physical interactions. Benefiting from the formation of dynamic TA/Fe³⁺ complexes within gel networks, the obtained hydrogel exhibited an intrinsic NIR absorption property for photothermal ablation of tumor cells, and enhanced cellular uptake of chemotherapeutic drugs. Both in vitro and in vivo experiments revealed that the injectable hydrogel exhibited an excellent biocompatibility and a synergistic therapeutic effect on tumor growth via combinational photothermal-chemotherapy. Therefore, this work provides a promising attempt to develop an injectable and NIR-responsive hydrogel from TA/Fe³⁺ complexes, which could work as a localized drug delivery platform for synergistic photothermal-chemotherapy.