Sensitive bioanalytical methods for telomerase activity detection: a cancer biomarker

Abstract

Telomerase is an enzyme that protects the length of telomeres by adding guanine-rich repetitive sequences. In tumors, gametes, and stem cells, telomerase activity is exerted. Telomerase activity can be a cancer biomarker for therapeutic and diagnosis approaches. So, a number of studies concentrating on the discovery of telomerase activity were reported. Bioanalytical devices, in comparison with other tests, have numerous advantages including low expense, simplicity, and excellent sensitivity and specificity. In this article we reviewed recent studies on the subject of various bioanalytical methods based on different nanomaterials. Optical, electrochemical, and quartz crystal microbalance (QCM) are prominent analytical techniques that are mentioned in this paper.