Synthesis of poly-tetrahydropyrimidine antibacterial polymers and research of their basic properties

Abstract

Modern medicine has increasingly higher requirements for antibacterial materials. To overcome this challenge, we use alkynyl monomers, amino monomers, formaldehyde, and acetic acid as raw materials to synthesize a series of poly-tetrahydropyrimidine (P-THP) polymers through multicomponent polymerizations (MCPs). P-THP polymers can effectively inhibit the growth of Gram-positive bacteria (Staphylococcus aureus, S. aureus) and Gram-negative bacteria (Escherichia. coli, E. coli), and can prevent bacteria from developing drug resistance within at least 16 generations. Besides, we prepared P-THP antibacterial coatings and explored their antibacterial properties. In vitro antibacterial experiments showed that P-THP coatings can prevent the formation of bacterial biofilms, and the coatings have a lasting killing effect on E. coli and S. aureus. The mouse wound infection experiments proved that P-THP polymers can significantly accelerate skin tissue regeneration and wound healing. Moreover, the P-THP textile obtained by electrospinning also has antibacterial properties and has great application prospects in the field of N95 masks. Generally speaking, P-THP polymers have considerable application potential in the field of treating bacterial infections and promoting wound healing.