Issue 15, 2022

Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

Abstract

We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.

Graphical abstract: Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

Supplementary files

Article information

Article type
Communication
Submitted
13 Sep 2021
Accepted
22 Dec 2021
First published
04 Jan 2022

Chem. Commun., 2022,58, 2468-2471

Osmium(VI) nitride triggers mitochondria-induced oncosis and apoptosis

M. Ye, W. Huang, Z. Li, C. Wang, T. Liu, Y. Chen, C. H. Hor, W. Man and W. Ni, Chem. Commun., 2022, 58, 2468 DOI: 10.1039/D1CC05148B

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