In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s

Yulong Kong; Kui Zeng; Ying Zhang; Jinning Shao; Jiaqi Yan; Jia-Yu Liao; Wenchao Wang; Xiaoyang Dai; Qinjie Weng; Shao Q. Yao; Su Zeng; Linghui Qian

doi:10.1039/D1CC06840G

In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s†

Yulong Kong,^a Kui Zeng,^a Ying Zhang,^a Jinning Shao,^a Jiaqi Yan,^a Jia-Yu Liao,^a Wenchao Wang,^a Xiaoyang Dai,^a Qinjie Weng,^a Shao Q. Yao,

^b Su Zeng*^a and Linghui Qian

*^a

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* Corresponding authors

^a Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou 310058, China
E-mail: zengsu@zju.edu.cn, lhqian@zju.edu.cn

^b Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore

Abstract

Cell-penetrating poly(disulfide)s (CPDs) are promising vehicles for cytosolic delivery of proteins. However, currently available arginine-rich CPD has rarely been reported for systemic delivery due to its “always” positive charge. Herein, we developed pH-responsive CPD_IMD that executes tumor targeting delivery via protonation of imidazole groups within the acidic tumor microenvironment.

This article is part of the themed collection: Chemical Communications HOT Articles 2022

Chemical Communications

In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s†

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In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s

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