Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in cells, demonstrating the feasibility of small-molecule mediated circRNA production.
L. Ni, T. Yamada, A. Murata and K. Nakatani, Chem. Commun., 2022, 58, 3629 DOI: 10.1039/D1CC06936E
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