Bimetallic metal–organic frameworks for tumor inhibition via combined photothermal-immunotherapy

Abstract

Herein, we report the design of therapeutic nanoparticles by encapsulating photosensitizers and aluminum ions into metal–organic frameworks. The nanoparticles could significantly inhibit the growth of primary and rechallenged tumors by a combination of photothermal therapy and immunotherapy. This work offers a promising strategy to design an immunologic nanoplatform for “cold” tumor therapy.