A highly selective 2′′-O-glycosyltransferase from Ziziphus jujuba and De novo biosynthesis of isovitexin 2′′-O-glucoside

Ya-Qun Zhang; Zi-Long Wang; Zhuo Chen; Zheng-Tong Jin; Aobulikasimu Hasan; Hai-Dong Wang; Yu-Wei Sun; Xue Qiao; Yong Wang; Min Ye

doi:10.1039/D1CC06949G

A highly selective 2′′-O-glycosyltransferase from Ziziphus jujuba and De novo biosynthesis of isovitexin 2′′-O-glucoside†

Ya-Qun Zhang,

‡^a Zi-Long Wang,

‡^a Zhuo Chen,‡^bc Zheng-Tong Jin,^a Aobulikasimu Hasan,^a Hai-Dong Wang,^a Yu-Wei Sun,^b Xue Qiao,

*^a Yong Wang*^b and Min Ye

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China
E-mail: qiaoxue@bjmu.edu.cn, yemin@bjmu.edu.cn

^b CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China
E-mail: yongwang@cemps.ac.cn

^c University of Chinese Academy of Sciences, Beijing 100039, China

Abstract

A novel and efficient 2′′-O-glycosyltransferase ZjOGT38 was identified from Ziziphus jujuba. It could regio-selectively glycosylate 2-hydroxyflavanone C-glycosides. ZjOGT38 allowed de novo biosynthesis of isovitexin 2′′-O-glucoside in E. coli.

Chemical Communications

A highly selective 2′′-O-glycosyltransferase from Ziziphus jujuba and De novo biosynthesis of isovitexin 2′′-O-glucoside†

Abstract

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A highly selective 2′′-O-glycosyltransferase from Ziziphus jujuba and De novo biosynthesis of isovitexin 2′′-O-glucoside

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