A novel NiVP/Pi-based flexible sensor for direct electrochemical ultrasensitive detection of cholesterol

Abstract

A novel non-enzymatic electrochemical sensor was constructed to achieve a highly selective and ultrasensitive detection of cholesterol to address the problems related to serious coronary heart disease. The NiVP/Pi-based sensor exhibited ultra-high sensitivity of 5510.18 μA μM⁻¹ cm⁻² and 36.8 μA μM⁻¹ cm⁻² for 1 nM to 10 μM and 100 μM to 10 mM of cholesterol, respectively, with an ultra-low detection limit of 1 aM, along with superior selectivity for cholesterol when exposed to various interferents such as ascorbic acid, glucose and uric acid. Also, a novel NiVP/Pi-based flexible sensor coated onto Whatman filter paper was developed and displayed superior sensitivity, even with a human blood serum sample at physiological pH.