Stable and sensitive ctDNA biosensing in complex biological fluid is highly important but still remains a challenge. Herein, we develop a spherical nucleic acid reporter-based cascade CRISPR/Cas12a amplifier with improved stability and sensitivity (5 orders of magnitude).
M. Zhou, Y. Yin, Y. Shi, Z. Huang, Y. Shi, M. Chen, G. Ke and X. Zhang, Chem. Commun., 2022, 58, 4508 DOI: 10.1039/D2CC00960A
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