Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis

Jinxing Hou; Xiaojia Jiang; Feihu Yang; Liang Wang; Tengfei Yan; Shengda Liu; Jiayun Xu; Chunxi Hou; Quan Luo; Junqiu Liu

doi:10.1039/D2CC01421A

Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis†

Jinxing Hou,^a Xiaojia Jiang,^a Feihu Yang,^a Liang Wang,^a Tengfei Yan,^b Shengda Liu,^b Jiayun Xu,^b Chunxi Hou,*^a Quan Luo

*^acd and Junqiu Liu

*^ab

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* Corresponding authors

^a State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, China
E-mail: chunxihou@jlu.edu.cn, luoquan@jlu.edu.cn, junqiuliu@jlu.edu.cn

^b College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China

^c Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China

^d Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China

Abstract

An artificial signal transduction model with a supramolecular recognition headgroup, a membrane anchoring group, and a pro-enzyme catalysis endgroup was constructed. The transmembrane translocation of the transducer can be reversibly regulated by competitive host–guest complexations as an input signal to control an enzyme reaction inside the lipid vesicles.

This article is part of the themed collection: Chemical Communications HOT Articles 2022

Chemical Communications

Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis†

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Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis

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