Multi-pathway inducing ferroptosis by MnO2-based nanodrugs for targeted cancer therapy

Shuhua Fan; Qiangqiang Yang; Qianna Song; Min Hong; Xiaoyan Liu; Haobin Chen; Juan Wang; Chuan Li; Shuang Cheng

doi:10.1039/D2CC02134J

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Multi-pathway inducing ferroptosis by MnO₂-based nanodrugs for targeted cancer therapy†

Shuhua Fan,‡^a Qiangqiang Yang,‡^a Qianna Song,^a Min Hong,

*^a Xiaoyan Liu,^a Haobin Chen,^a Juan Wang,^a Chuan Li^a and Shuang Cheng*^b

Author affiliations

* Corresponding authors

^a School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong, China
E-mail: hongmin@lcu.edu.cn

^b School of Agriculture, Liaocheng University, Liaocheng, Shandong, China
E-mail: chengshuang@lcu.edu.cn

Abstract

A multifunctional nanodrug (Tf–DHA–ASO–MnO₂) based on manganese dioxide nanosheets was constructed by triple-dressing with transferrin, dihydroartemisinin, and antisense oligonucleotide sequences. Tf–DHA–ASO–MnO₂ shows an effective targeted cancer therapy ability through the ferroptosis caused by the production of excessive lipid peroxides resulting from the combined effect of glutathione exhaustion, reactive oxygen species generation and down-regulation of glutathione peroxidase 4.

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Article information

DOI: https://doi.org/10.1039/D2CC02134J
Article type: Communication
Submitted: 14 Apr 2022
Accepted: 26 Apr 2022
First published: 05 May 2022

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Chem. Commun., 2022,58, 6486-6489

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Multi-pathway inducing ferroptosis by MnO₂-based nanodrugs for targeted cancer therapy

S. Fan, Q. Yang, Q. Song, M. Hong, X. Liu, H. Chen, J. Wang, C. Li and S. Cheng, Chem. Commun., 2022, 58, 6486 DOI: 10.1039/D2CC02134J

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Chemical Communications