Issue 83, 2022
From the journal:

Chemical Communications

Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus, targets peptidoglycan biosynthesis†

Viral Rawat,‡a   Sona Tiwari,‡a   Shweta Khanna,‡a   Umang Gupta,b   Sridhar S. N. C.,a   Dharmendra K. Yadav,a   Grace Kaul,cd   Abdul Akhir,c   Deepanshi Saxena,c   Saravanan Matheshwaran, ORCID logo b   Sidharth Chopracd  and  Dharmaraja Allimuthu ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Kanpur, Uttar Pradesh 208016, India
E-mail: atdharma@iitk.ac.in

b Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Uttar Pradesh 208016, India

c Division of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India

d AcSIR: Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

Abstract

Antimicrobial resistance (AMR) is a global health concern. Targetting AMR, we present an in situ lactonization mechanism generating 4-nitroisobenzofuran-1(3H)-one (IITK2020), an exclusive S. aureus inhibitor at 2–4 μg mL−1 MIC including multidrug-resistant S. aureus clinical strains, that prevents peptidoglycan biosynthesis.

Graphical abstract: Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus, targets peptidoglycan biosynthesis

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Article information

DOI
https://doi.org/10.1039/D2CC04102B
Article type
Communication
Submitted
22 Jul 2022
Accepted
15 Sep 2022
First published
16 Sep 2022

Chem. Commun., 2022,58, 11669-11672

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Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus, targets peptidoglycan biosynthesis

V. Rawat, S. Tiwari, S. Khanna, U. Gupta, S. S. N. C., D. K. Yadav, G. Kaul, A. Akhir, D. Saxena, S. Matheshwaran, S. Chopra and D. Allimuthu, Chem. Commun., 2022, 58, 11669 DOI: 10.1039/D2CC04102B

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