Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

Ying Zhang; Qianyu Zhang; Zheng Chu; Lin Chen; Jiayun Chen; Yang Yang; Huan Tang; Guangqing Cheng; Ang Ma; Ying Zhang; Chen Wang; Peng Gao; Fei Xia; Qiuyan Guo; Qiaoli Shi; Guang Han; Jigang Wang; Yinhua Zhu

doi:10.1039/D2CC05278D

Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells†

Ying Zhang,‡^a Qianyu Zhang,‡^b Zheng Chu,‡^a Lin Chen,‡^a Jiayun Chen,^a Yang Yang,^a Huan Tang,^a Guangqing Cheng,^a Ang Ma,^a Ying Zhang,^a Chen Wang,^a Peng Gao,^a Fei Xia,

^a Qiuyan Guo,^a Qiaoli Shi,^a Guang Han,*^b Jigang Wang

*^ac and Yinhua Zhu*^a

Author affiliations

* Corresponding authors

^a Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
E-mail: yhzhu@icmm.ac.cn, jgwang@icmm.ac.cn

^b Pharmaceutical College, Henan University, Kaifeng, China
E-mail: hang@henu.edu.cn

^c Department of Nephrology, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China

Abstract

Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic and further revealed that it might target a class of glutathione S-transferases to activate ROS-p38 signaling and induce apoptosis in senescent cells.

Chemical Communications

Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells†

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Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

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