A {Cd4Cl2O14} cluster functionalized sandwich-type tungstoarsenate as a conformation modulator for misfolding Aβ peptides

Jiai Hua; Xueman Wei; Xiang Ma; Jinzhe Jiao; Binghui Chai; Chenbin Wu; Changli Zhang; Yulan Niu

doi:10.1039/D1CE01637G

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A {Cd₄Cl₂O₁₄} cluster functionalized sandwich-type tungstoarsenate as a conformation modulator for misfolding Aβ peptides†

Jiai Hua,

‡*^a Xueman Wei,‡^b Xiang Ma,

*^a Jinzhe Jiao,^c Binghui Chai,^c Chenbin Wu,^a Changli Zhang*^d and Yulan Niu*^c

Author affiliations

* Corresponding authors

^a Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan, P. R. China
E-mail: jiaihua10660@163.com, maxiang@tit.edu.cn
Fax: +86 351 3569476

^b Department of Geriatrics, First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China
E-mail: wxmshchyy@163.com

^c Laboratory of Biochemistry and Pharmacy, Taiyuan Institute of Technology, Taiyuan, P. R. China
E-mail: Niuyl@tit.edu.cn

^d School of Environmental Science, Nanjing Xiaozhuang University, Nanjing, P. R. China
E-mail: zhangcl@njxzc.edu.cn

Abstract

A nanoscale polyoxometalate {[H₂dap]₆[Cd₄Cl₂(B-α-AsW₉O₃₄)₂]} based on a tetra-Cd cluster sandwiched by trivacant Keggin-type tungstoarsenate was successfully designed and synthesized. It can modulate the β-sheet-rich fibrils of Aβ peptides efficiently and thus inhibits the production of reactive oxygen species originating from these Aβ aggregates.

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Article information

DOI: https://doi.org/10.1039/D1CE01637G
Article type: Communication
Submitted: 09 Dec 2021
Accepted: 09 Jan 2022
First published: 10 Jan 2022

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CrystEngComm, 2022,24, 1171-1176

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A {Cd₄Cl₂O₁₄} cluster functionalized sandwich-type tungstoarsenate as a conformation modulator for misfolding Aβ peptides

J. Hua, X. Wei, X. Ma, J. Jiao, B. Chai, C. Wu, C. Zhang and Y. Niu, CrystEngComm, 2022, 24, 1171 DOI: 10.1039/D1CE01637G

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