Synthesis of carbon-11 radiolabelled transition metal complexes using 11C-dithiocarbamates

Abstract

A novel radiolabelling method exploiting ¹¹C-dithiocarbamate ligands has been used to generate ¹¹C-labelled Au(I), Au(III), Pd(II) and Pt(II) complexes in high radiochemical yields (71–99%). Labelled complexes were prepared in a rapid one-pot procedure via the substitution reaction of ¹¹C-dithiocarbamate ligands with appropriate transition metal chloride precursors.