Issue 4, 2022

Directing the H2-driven selective regeneration of NADH via Sn-doped Pt/SiO2

Abstract

H2-Driven NADH regeneration has long suffered from low selectivity when non-enzymatic, particularly heterogeneous catalysts, are used. In addition to the unselective nature of the catalysts, the typically unmeasured NAD+ conversion has inevitably hindered catalyst development. Here we report Sn-doped Pt/SiO2 catalysts for the selective regeneration of NADH and show that doping Pt/SiO2 with 10 at% Sn can deliver a selectivity of 90% (at full conversion) using H2. We propose that this is a result of Sn disturbing the Pt ensemble, altering the mode of NAD+ adsorption and directing the reduction to the 1,4-position of the nicotinamide ring.

Graphical abstract: Directing the H2-driven selective regeneration of NADH via Sn-doped Pt/SiO2

Supplementary files

Article information

Article type
Communication
Submitted
26 Nov 2021
Accepted
31 Jan 2022
First published
31 Jan 2022
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2022,24, 1451-1455

Directing the H2-driven selective regeneration of NADH via Sn-doped Pt/SiO2

J. W. H. Burnett, J. Li, A. J. McCue, P. N. Kechagiopoulos, R. F. Howe and X. Wang, Green Chem., 2022, 24, 1451 DOI: 10.1039/D1GC04414A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements