Issue 12, 2022

Alumina-mediated soft propargylic C–H activation in unactivated alkynes

Abstract

The discovery and development of new synthetic methods exploiting earth-abundant-element-based catalysts is an important goal in contemporary synthetic organic chemistry, which faces increasingly stringent requirements of sustainability. In this work, we disclose alumina-mediated propargylic C–H activation inducing a challenging transformation of readily available alkynes into a valuable 1,3-diene moiety under unprecedentedly mild conditions. Combining DFT-investigation and synthetic observations, we demonstrate that partial hydroxylation of alumina's surface might play an essential role in this process.

Graphical abstract: Alumina-mediated soft propargylic C–H activation in unactivated alkynes

Supplementary files

Article information

Article type
Communication
Submitted
10 Feb 2022
Accepted
29 Mar 2022
First published
30 Mar 2022

Green Chem., 2022,24, 4761-4765

Alumina-mediated soft propargylic C–H activation in unactivated alkynes

M. Feofanov, D. I. Sharapa and V. Akhmetov, Green Chem., 2022, 24, 4761 DOI: 10.1039/D2GC00555G

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