Alumina-mediated soft propargylic C–H activation in unactivated alkynes†
Abstract
The discovery and development of new synthetic methods exploiting earth-abundant-element-based catalysts is an important goal in contemporary synthetic organic chemistry, which faces increasingly stringent requirements of sustainability. In this work, we disclose alumina-mediated propargylic C–H activation inducing a challenging transformation of readily available alkynes into a valuable 1,3-diene moiety under unprecedentedly mild conditions. Combining DFT-investigation and synthetic observations, we demonstrate that partial hydroxylation of alumina's surface might play an essential role in this process.