Electrolyte-free electrochemical C–H trifluoromethylation of 2-pyridones under batch and flow conditions

Abstract

Herein, we report direct C3 trifluoromethylation of 2-pyridones including unprotected derivatives by an electrochemical approach using the readily available Langlois reagent as the CF₃ source in the absence of electrolytes. The trifluoromethylation under transition metal- and oxidant-free conditions occurred site-selectively to give the desired products in moderate to good yields under ambient conditions. Interestingly, significant acceleration rates, improved yields and selectivities as well as reduced energy consumption were achieved under microfluidic conditions.