Issue 7, 2022

Evaluation of blood and synthetic matrix-matched calibrations using manual and inline sample preparation methods

Abstract

Biomonitoring and clinical testing are important for improving human health. These tests help public health officials or medical doctors monitor the levels of essential elements and assess exposure to toxic or potentially toxic elements within the human body. While a great deal of work has been published on biomonitoring and clinical analyses, the majority of the work has been performed with manual sample preparation. This work will explore the use of two different automation platforms for clinical analyses, one for high-throughput sampling of manually prepared blood samples and the second an inline whole blood preparation method with micro-volume sampling. The comparison and validation of these systems was carried out by analyzing 2019 New York Department of Health Proficiency Testing samples that had known reference ranges for the analytes of interest (Cd, Hg, Mn, Se, and Pb). In addition, the ICP-MS methods were calibrated using two different matrix options, purchased base blood and synthetic clinical matrix, which were compared for background levels, detection limits, and accuracy relative to the reported reference values for the New York Department of Health Proficiency Testing samples.

Graphical abstract: Evaluation of blood and synthetic matrix-matched calibrations using manual and inline sample preparation methods

Supplementary files

Article information

Article type
Paper
Submitted
21 Feb 2022
Accepted
11 May 2022
First published
01 Jun 2022
This article is Open Access
Creative Commons BY license

J. Anal. At. Spectrom., 2022,37, 1512-1521

Evaluation of blood and synthetic matrix-matched calibrations using manual and inline sample preparation methods

C. D. Quarles, N. Bohlim, K. Wiederin, N. Saetveit and P. Sullivan, J. Anal. At. Spectrom., 2022, 37, 1512 DOI: 10.1039/D2JA00056C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements