Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

Yan Zhang; Sungho Kim; Weihua Shi; Yaoyao Zhao; Insu Park; Christopher Brenden; Hrishikesh Iyer; Prasoon Jha; Rashid Bashir; Jonathan V. Sweedler; Yurii Vlasov

doi:10.1039/D1LC00758K

Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform†

Yan Zhang,^a Sungho Kim,

^a Weihua Shi,^a Yaoyao Zhao,^b Insu Park,^c Christopher Brenden,

^c Hrishikesh Iyer,^a Prasoon Jha,^a Rashid Bashir,

^c Jonathan V. Sweedler

^b and Yurii Vlasov

*^ac

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* Corresponding authors

^a Department of Electrical and Computer Engineering, University of Illinois Urbana Champaign, IL 61801, USA
E-mail: yvlasov@illinois.edu

^b Department of Chemistry and the Beckman Institute, University of Illinois Urbana Champaign, IL 61801, USA

^c Department of Bioengineering, University of Illinois Urbana Champaign, IL 61801, USA

Abstract

We report a silicon microfluidic platform that enables monolithic integration of transparent micron-scale microfluidic channels, an on-chip segmentation of analyte flows into picoliter-volume droplets, and a nano-electrospray ionization emitter that enables spatial and temporal separation of oil and aqueous phases during electro-spray for subsequent mass spectrometry analysis.

Lab on a Chip

Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform†

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Droplet-assisted electrospray phase separation using an integrated silicon microfluidic platform

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