Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

Keisuke Oshimi; Yushi Nishimura; Tsutomu Matsubara; Masuaki Tanaka; Eiji Shikoh; Li Zhao; Yajuan Zou; Naoki Komatsu; Yuta Ikado; Yuka Takezawa; Eriko Kage-Nakadai; Yumi Izutsu; Katsutoshi Yoshizato; Saho Morita; Masato Tokunaga; Hiroshi Yukawa; Yoshinobu Baba; Yoshio Teki; Masazumi Fujiwara

doi:10.1039/D2LC00112H

Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples†

Keisuke Oshimi,^ab Yushi Nishimura,^bc Tsutomu Matsubara,^d Masuaki Tanaka,^e Eiji Shikoh,^e Li Zhao,^f Yajuan Zou,^ag Naoki Komatsu,^g Yuta Ikado,^a Yuka Takezawa,^h Eriko Kage-Nakadai,^h Yumi Izutsu,ⁱ Katsutoshi Yoshizato,^j Saho Morita,^k Masato Tokunaga,^k Hiroshi Yukawa,

^klc Yoshinobu Baba,^klc Yoshio Teki

^b and Masazumi Fujiwara

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
E-mail: masazumi@okayama-u.ac.jp

^b Department of Chemistry, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan

^c Institute for Quantum Life Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan

^d Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan

^e Department of Electrical and Information Engineering, Graduate School of Engineering, Osaka City University, Osaka 558-8585, Japan

^f State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, P. R. China

^g Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan

^h Department of Human Life Science, Graduate School of Food and Human Life Science, Osaka City University, Osaka 558-8585, Japan

ⁱ Department of Biology, Faculty of Science, Niigata University, Niigata 950-2181, Japan

^j Synthetic biology laboratory, Graduate school of medicine, Osaka City University, Osaka 545-8585, Japan

^k Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan

^l Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Nagoya 464-8603, Japan

Abstract

We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm²) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

This article is part of the themed collection: Lab on a Chip HOT Articles 2022

Lab on a Chip

Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples†

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Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

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