Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)

Yota Okuno; Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi

doi:10.1039/D2NA00218C

Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)†

Yota Okuno,

^ab Tomoki Nishimura,

^c Yoshihiro Sasaki

^a and Kazunari Akiyoshi*^a

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* Corresponding authors

^a Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: akiyoshi.kazunari.2e@kyoto-u.ac.jp

^b Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35, Yamanote-cho, Suita City, Osaka, Japan

^c Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, 3-15-1, Tokida, Nagano 386-8567, Japan

Abstract

Conjugation of maltopentaose to water-soluble homo-poly(sarcosine) induced self-association and formed nanospheres (−150 nm) in water although homo-poly(sarcosine) was water-soluble and did not form any aggregates. Fluorescent probe experiments showed that the spheres were non-ionic glycopeptoid coacervate-like particles with both hydrophobic and hydrophilic domains inside.

This article is part of the themed collection: Popular Advances

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DOI: https://doi.org/10.1039/D2NA00218C
Article type: Communication
Submitted: 07 Apr 2022
Accepted: 25 Jun 2022
First published: 27 Jun 2022
This article is Open Access

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Nanoscale Adv., 2022,4, 3707-3710

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Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)

Y. Okuno, T. Nishimura, Y. Sasaki and K. Akiyoshi, Nanoscale Adv., 2022, 4, 3707 DOI: 10.1039/D2NA00218C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Nanoscale Advances

Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)†

Abstract

Supplementary files

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Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)

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