Divergent synthesis of isoxazoles and 6H-1,2-oxazines via hypervalent iodine-mediated intramolecular oxygenation of alkenes

Abstract

The divergent synthesis of isoxazoles and 6H-1,2-oxazines was realized using a hypervalent fluoroiodane reagent from β,γ-unsaturated oximes. The formation of a five- or six-membered ring is controlled by the substituents of the substrates combined with the reaction conditions. The reaction was performed under mild conditions and gave the products in moderate to good yields.