Asymmetric oxidative Mannich reactions promoted by photocatalysis and electrochemistry

Abstract

The asymmetric Mannich reaction is an essential method in contemporary organic chemistry. As a representative of clean and green synthesis methods, photochemical and electrochemical oxidation strategies have re-emerged in recent years, providing new ideas for asymmetric Mannich reactions. Numerous chiral β-amino carbonyl compounds have been accessed in satisfactory yields with excellent enantioselectivity via such novel asymmetric oxidative Mannich reactions. This minireview highlights plentiful advances in asymmetric oxidative Mannich reactions that rely on photoredox or anodic-oxidation and covers the literature from 2014 to date. Furthermore, the future development of this field is envisaged.