Transition-metal-free electrochemical oxidative C(sp2)–H trifluoromethylation of aryl aldehyde hydrazones

Abstract

A simple protocol of metal-free C–H trifluoromethylation of hydrazones via electrolysis was developed. This environment-friendly transformation showed high efficiency, good tolerance, and scaled-up functionalization, providing the desired products in moderate to good yields. At the same time, a high yield can be obtained for the substrates either bearing an electron-donating group or an electron-withdrawing group by using different trifluoromethyl reagents. In addition, the radical mechanism was confirmed by the control experiment.