Issue 8, 2022

808 nm NIR-triggered Camellia sapogein/curcumin-based antibacterial upconversion nanoparticles for synergistic photodynamic-chemical combined therapy

Abstract

Antibacterial upconversion nanoparticles (UCNP)-based photodynamic-chemical combined therapy (UCNP-aPCCT) provides an ideal method to solve the problem of antibiotic-resistant bacteria in deep-tissue infections. Saponin is a kind of natural product exhibiting promising antibacterial activity. Curcumin is also a natural product that could be used as photosensitizer for antibacterial photodynamic therapy (aPDT). Herein, we have designed the dual-layer silica-coated upconversion nanoparticles combined with UCNP-photodynamic therapy (PDT) and chemotherapy using curcumin as a photosensitizer and the Camellia sapogenin derivative (CSD) as an antibacterial agent. It turned out that the prepared UCNP@mSiO2(Cur)@DmSiO2(CSD)@PVP nanoparticles displayed high antibacterial activity against Escherichia coli and Staphylococcus aureus under near-infrared (NIR) irradiation at 808 nm. Its antibacterial activity is stronger than that of the simple sum of saponin and curcumin aPDT, indicating the existence of a synergetic photodynamic-chemical effect. The current nanoparticle drug system may have potential applications for deep-tissue anti-infection treatment.

Graphical abstract: 808 nm NIR-triggered Camellia sapogein/curcumin-based antibacterial upconversion nanoparticles for synergistic photodynamic-chemical combined therapy

Supplementary files

Article information

Article type
Research Article
Submitted
16 Dec 2021
Accepted
01 Mar 2022
First published
01 Mar 2022

Inorg. Chem. Front., 2022,9, 1836-1846

808 nm NIR-triggered Camellia sapogein/curcumin-based antibacterial upconversion nanoparticles for synergistic photodynamic-chemical combined therapy

Z. Liu, X. Tang, C. Huang, J. Zhang, W. Huang and Y. Ye, Inorg. Chem. Front., 2022, 9, 1836 DOI: 10.1039/D1QI01569A

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