Issue 2, 2022

Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin

Abstract

Metformin (MET) is an important oral hypoglycemic agent for type 2 diabetes via inhibiting gluconeogenesis in the liver and increasing the sensitivity of the receptor to insulin. It also displays a wide range of therapeutic effects towards many other diseases, including different kinds of cancers, bone disorders, inflammation and even aging and microbial infections. Despite its widespread clinical applications, administration of MET in clinics is still restricted due to the relatively low bioavailability, short half-life, and side effects. To overcome these limitations, various types of nanoparticulate drug delivery systems, including proteins, polymers and inorganic nanoparticles for loading and delivering MET, have been reported. In this review, nanoparticle-based drug delivery systems for delivering MET are summarized in the first part. The biomedical applications of these nanoparticle-based drug delivery systems are introduced in the following section. Finally, the combination therapy based on the drug delivery systems for MET is also discussed. We trust that this review article will attract great attention from scientists from chemistry, materials, biological and medical fields.

Graphical abstract: Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin

Article information

Article type
Review Article
Submitted
17 Sep 2021
Accepted
03 Nov 2021
First published
12 Nov 2021

Mater. Chem. Front., 2022,6, 128-144

Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin

X. Yang, Q. Lai, X. Yang, B. Xie, B. Zhang, X. Zhang and Y. Wei, Mater. Chem. Front., 2022, 6, 128 DOI: 10.1039/D1QM01277K

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