Issue 18, 2022

Copper depletion combined with photothermal therapy suppresses breast cancer

Abstract

Metal ions play an important role in cancer growth, so the chelating agents of metal ions are potential therapeutics for cancer treatment. In this paper, a dye molecule (PY-TBDP) with both copper chelation and photothermal conversion properties was designed and synthesized. Stable nanoparticles of PY-TBDP (PY-TBDP NPs) can be obtained in the presence of MPEG2000-DSPE. PY-TBDP NPs can rapidly bind to copper ions and show high photothermal conversion ability (η = 40%) upon irradiation. Compared with copper chelation or photothermal therapy alone, the combination of the two therapies exhibits enhanced antitumor effect. This work demonstrates the great potential of metal chelating agents in disease treatment.

Graphical abstract: Copper depletion combined with photothermal therapy suppresses breast cancer

Supplementary files

Article information

Article type
Research Article
Submitted
13 May 2022
Accepted
01 Aug 2022
First published
03 Aug 2022

Mater. Chem. Front., 2022,6, 2735-2740

Copper depletion combined with photothermal therapy suppresses breast cancer

C. Li, D. Hao, X. Wang, T. Sun and Z. Xie, Mater. Chem. Front., 2022, 6, 2735 DOI: 10.1039/D2QM00445C

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