Visible-light-mediated regioselective ring-opening hydrogenolysis of donor–acceptor cyclopropanes with DIPEA and H2O

Abstract

In this paper, a visible-light-mediated regioselective ring-opening hydrogenolysis of donor–acceptor cyclopropanes has been disclosed for the rapid construction of alkylated aryl ketones in moderate to excellent yields with good functional group compatibility under mild conditions. As compared with the previously reported hydrogenolysis protocols, this photo-induced method features a facile and practical process to access a variety of alkylated aryl ketones with low cost reductant. The mechanistic paradigm has been proposed on the basis of control, deuterium labeling, and ¹H NMR tracing experiments.