Palladium-catalyzed cascade Heck-type thiocarbonylation for the synthesis of functionalized thioesters

Abstract

A palladium-catalyzed cascade Heck-type cyclization and carbonylation reaction has been developed for the synthesis of functionalized thioesters. With arylsulfonyl chlorides as odorless and readily available sulfur sources, a variety of thioesters were obtained in moderate to good yields with good functional group compatibility. In this system, Mo(CO)₆ acts as both a convenient CO surrogate and a suitable reductant.