Visible-light-promoted denitrogenative ortho-selenylation reaction of benzotriazinones: synthesis of ortho-selenylated benzamides and ebselen analogs

Abstract

A visible-light-promoted regioselective denitrogenative cross-coupling between benzotriazinones and selenosulfonates is reported. This protocol allows for the convenient synthesis of ortho-selenylated benzamides in good yields from readily available starting materials under mild conditions with a general substrate scope. This protocol has been further applied to a one-pot two-step synthesis of a series of ebselen and its analogs.