Issue 9, 2022

A general synthesis of aromatic amides via palladium-catalyzed direct aminocarbonylation of aryl chlorides

Abstract

The direct palladium-catalyzed selective carbonylative coupling of less reactive aryl chlorides (including electron-rich, -neutral and -deficient ones) with primary and secondary aliphatic and aromatic amines is described for the first time. Key for the success of this transformation is the use of a palladium/Xantphos catalyst system in the presence of cesium chloride (CsCl) as additive. In general, this catalytic system allows for efficient conversion of diverse aryl chlorides with an array of amines and with good functional group compatibility (60 examples, conversion up to 99%, isolated yield up to 95%).

Graphical abstract: A general synthesis of aromatic amides via palladium-catalyzed direct aminocarbonylation of aryl chlorides

Supplementary files

Article information

Article type
Research Article
Submitted
15 Feb 2022
Accepted
20 Mar 2022
First published
22 Mar 2022

Org. Chem. Front., 2022,9, 2491-2497

A general synthesis of aromatic amides via palladium-catalyzed direct aminocarbonylation of aryl chlorides

P. Wang, J. Yang, K. Sun, H. Neumann and M. Beller, Org. Chem. Front., 2022, 9, 2491 DOI: 10.1039/D2QO00251E

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