Issue 10, 2022

Base-promoted anaerobic intramolecular cyclization synthesis of 4,5-disubstituted-1,2,3-thiadiazoles

Abstract

An alkali-promoted, transition-metal-free and oxidant-free method to construct 4,5-disubstituted-1,2,3-thiadiazoles from N-tosylhydrazone-bearing thiocarbamates by employing a sustainable intramolecular reaction strategy has been developed. This reaction features high efficiency and good functional group compatibility, readily available starting materials and valuable products. Furthermore, this method has great potential in the synthesis of natural products, pharmaceuticals and materials.

Graphical abstract: Base-promoted anaerobic intramolecular cyclization synthesis of 4,5-disubstituted-1,2,3-thiadiazoles

Supplementary files

Article information

Article type
Research Article
Submitted
02 Mar 2022
Accepted
29 Mar 2022
First published
30 Mar 2022

Org. Chem. Front., 2022,9, 2647-2652

Base-promoted anaerobic intramolecular cyclization synthesis of 4,5-disubstituted-1,2,3-thiadiazoles

C. Dong, S. Mai, S. Wang, X. Li and Q. Song, Org. Chem. Front., 2022, 9, 2647 DOI: 10.1039/D2QO00351A

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